Research

Neuro-inflammation

Neuro-inflammation research at CENABH investigates how the brain’s immune responses influence health and disease, with a strong focus on molecular mechanisms underlying neurodegenerative disorders, learning, and memory. We examine how microglia, astrocytes, and inflammatory mediators contribute to neuronal plasticity, synaptic function, and cognitive outcomes. Particular emphasis is placed on how age-related changes and pregnancy-associated physiological states modify inflammatory pathways and alter disease vulnerability. By mapping signaling cascades and immune–neural interactions, we aim to identify biomarkers and therapeutic targets that can guide precision strategies to protect brain function and reduce the burden of neurodegeneration across diverse life stages.

Gut–Brain Axis

Gut–Brain Axis research at CENABH investigates how intestinal microbiota regulate diverse neuronal activities and cognitive functions through intricate molecular interactions with the central nervous system. We study how microbial metabolites cross physiological barriers and modulate neurotransmission, synaptic plasticity, and memory processes. Particular focus is given to how alterations in gut microbial composition contribute to neurodegenerative diseases, influencing progression and severity. By mapping microbial and metabolite signatures linked to these conditions, our goal is to establish early diagnostic biomarkers and identify therapeutic strategies that enable precise, timely management of neurological disorders through microbiome-informed molecular approaches.

Stem Cell and Neuron Regeneration

Stem Cell and Neuron Regeneration research at CENABH focuses on isolating stem cells from key neurogenic niches such as the dentate gyrus (DG) and subventricular zone (SVZ) to study their potential in repairing damaged brain circuits. We investigate how these stem cells differentiate into neurons, integrate into synaptic networks, and support functions such as learning, memory, and plasticity. A major emphasis is on Ciliary Neurotrophic Factor (CNTF), traditionally known for neuroprotection but now recognized for promoting neurogenesis. By identifying CNTF-activated pathways and genes regulating neuronal differentiation and synaptic transmission, we aim to advance therapeutic strategies for halting early neurodegeneration and improving cognition.

Nutraceutical Development for Brain Health

The Nutraceutical Development theme is dedicated to designing natural products that strengthen and protect the brain. At CENABH, we investigate bioactive compounds derived from plants, marine organisms, and functional foods for their neuroprotective, anti- inflammatory, and cognitive-enhancing properties. Using advanced biochemical and molecular tools, our goal is to validate traditional knowledge and develop evidence-based nutraceuticals for brain health. This research also emphasizes preventive strategies, supporting cognitive resilience across the lifespan and reducing the burden of age-related disorders. Ultimately, our focus is on safe, accessible, and scientifically validated nutraceutical solutions that promote brain vitality and long-term wellness.

Neuroinformatics

CENABH’s Neuroinformatics research integrates neuroscience with computational and data science to decode the complexity of neuronal dynamics. By applying artificial intelligence, computational modeling, and big data analytics, we analyze high-dimensional datasets from genomics, transcriptomics, proteomics, metabolomics, and imaging studies. This approach facilitates biomarker discovery, predictive modeling, and early diagnosis of neurodegenerative diseases. We also develop interactive tools and databases to support knowledge sharing and collaborative research. By merging multi-omics data with computational insights, our goal is to enable precision medicine, uncover mechanistic pathways, and accelerate the translation of discoveries into targeted interventions that enhance neurological health and cognitive outcomes.

Cancer Neuroscience

The Cancer Neuroscience Division at CENABH explores the complex interactions between the tumor microenvironment (TME) and the neuronal niche. Our research investigates how tumor cells, cancer-associated fibroblasts (CAFs), and immune cells dynamically interact with neurons to modulate tumor initiation, progression, invasion, and metastasis. Concurrently, we explore the TME alterations associated with diabetes, aiming to understand how metabolic changes impact tumor–nerve interactions. Through these studies, we aim to identify novel neuro–tumoral regulatory pathways that could be targeted for therapeutic intervention.

Additionally, we also investigate the gut–cancer axis in central nervous system malignancies, particularly glioblastoma. We focus on how gut microbial metabolites influence glioblastoma progression and modulate its neural and immune microenvironment, aiming to uncover mechanistic links between gut microbiota, tumor biology, and neuron, immune interactions in glioblastoma.

Neuroregenerative Medicine

CENABH’s Neuroregenerative Medicine research focuses on advancing cell-based strategies for Parkinson’s disease (PD). Our primary interest is isolating progenitor cells from peripheral blood mononuclear cells (PBMNCs) and differentiating them into functional dopaminergic neurons using a patented protocol. We investigate how these neurons integrate into host circuits, restore synaptic function, and promote neuronal recovery when transplanted into standardized preclinical PD models generated by selective dopaminergic degeneration. The efficacy of transplantation is evaluated through behavioral, molecular, and physiological studies. Through this translational strategy, we aim to establish reliable regenerative interventions that move beyond symptomatic relief to transform the treatment of neurodegenerative diseases.

Developmental Neuroscience

This research area investigates how early-life lung injury in preterm infants influences brain development, cognitive outcomes, and the risk of neurodevelopmental disorders such as Autism Spectrum Disorder (ASD). Specifically, our work focuses on the molecular, cellular, and pathological mechanisms through which Bronchopulmonary Dysplasia (BPD), a major complication of prematurity, affects neurodevelopment. Utilizing preclinical rodent models and in vitro systems, we integrate molecular, histopathological, and neurobehavioral analyses to delineate the interdependence between lung and brain injury. Our studies emphasize transcriptional, proteomic, and metabolomic signatures associated with inflammation, oxidative stress, and disrupted signaling pathways. Furthermore, we aim to elucidate the mechanisms mediating bidirectional lung–brain communication by identifying key signaling mediators and cellular pathways involved in this cross-talk. Ultimately, our goal is to define therapeutic targets and intervention strategies that mitigate both pulmonary and neural injury, thereby improving neurodevelopmental outcomes.

Translational Social Neuroscience

CENABH’s Social Neuroscience program serves as a bridge between laboratory science and community well-being. Guided by a translational vision, this research theme transforms neuroscience discoveries into actionable interventions that improve mental and social health. Through Prajñā, our dedicated community interface, we conduct action research and ethnographic studies to identify real-world barriers to brain health and implement evidence-based initiatives such as mindfulness training, neuro-literacy programs, and community workshops. This approach ensures that our scientific insights evolve into inclusive and accessible social applications.

Interdisciplinary Neuroscience and Society

We view the brain as both a biological and social entity. This theme integrates neuroscience with social psychology, anthropology, and cultural studies to understand how relationships, environments, and traditions shape cognition and behavior. CENABH promotes a holistic framework that investigates how social and cultural contexts influence neural development and mental health outcomes. Through partnerships with government bodies, NGOs, and local communities, we co-develop sustainable, culturally attuned models for mental well-being and social resilience.

Community Neuroscience: Aging and Neurodiversity

Our Community Neuroscience initiatives focus on empowering vulnerable populations, particularly the elderly and neurodiverse individuals. Building on our flagship Bodhi: Dementia-Friendly Ernakulam project, we are developing intergenerational “Neuro-Buddy” programs that foster cognitive vitality and social connectedness among older adults. Simultaneously, we aim to create “Sensory-Friendly” certifications for public spaces and implement Peer-Mediated Interventions (PMI) in schools, fostering naturalistic social development in autistic individuals. Together, these initiatives create inclusive, brain-friendly communities that value neurodiversity and healthy aging.

Neuroeducation and Social-Emotional Learning

CENABH’s Neuroeducation program pioneers a neuroscience-informed approach to teaching and learning. We develop and evaluate “Neuro-Literacy” modules that teach students about empathy and emotional regulation through the lens of brain science, reducing stigma and enhancing mental health awareness. Our Mindful Schools initiative integrates mindfulness and cognitive reappraisal training for students and teachers, strengthening prefrontal control and emotional resilience. By embedding neuroscience into education, we cultivate emotionally intelligent, self-aware learners equipped for lifelong well-being.

Neurodevelopment and Rehabilitation

This theme applies neurodevelopmental insights to reshape rehabilitation and juvenile justice systems. CENABH’s Trauma-Informed Justice initiative studies how early adversity and chronic stress impact the developing brain—particularly the prefrontal cortex and amygdala—and how these neural changes influence decision-making and emotional regulation. By implementing Mindfulness-Based Cognitive Therapy (MBCT) in detention centers and training justice professionals in neurodevelopmental principles, we promote compassionate, evidence-based approaches that harness neuroplasticity to support positive behavioral transformation.

Neuroeconomics and Public Policy

CENABH integrates neuroscience and behavioral science to design policies that nudge society toward healthier, more sustainable lifestyles. By studying how the brain processes reward, risk, and social norms, we develop strategies for framing public health messages and shaping decision environments. In partnership with civic bodies, we apply “Choice Architecture” principles to public canteens, schools, and markets—making healthy, prosocial choices the easy default. This theme exemplifies how neuroscience can inform governance, shaping environments that enhance collective well-being.